The year is 1954. U.S. Marshal Teddy Daniels and his new partner, Chuck Aule, have come to Shutter Island, home of Ashecliffe Hospital for the Criminally Insane, to investigate the disappearance of a patient. Multiple murderess Rachel Solando is loose somewhere on this remote and barren island, despite having been kept in a locked cell under constant surveillance. As a killer hurricane bears relentlessly down on them, a strange case takes on even darker, more sinister shades.